CH-5.1 D Pharm Pharmacology

Topic: Anti-anginal drugs

Antianginal drugs are used to provide immediate relief from symptoms and prevent angina attacks.

Classification of Anti-anginal drugs:

A. Vasodilator:

1. Nitrates:

a) Short duration: Glyceryl trinitrate (GTN, Nitroglycerine)

b) Intermediate duration: Oral Nitroglycerine

c) Long duration: Isosorbide dinitrate (short acting by sublingual route), Isosorbide,

    mononitrate, Erythrityl tetranitrate, Pentaerythritol tetranitrate

2. Calcium Channel Blocker:

      a) Phenyl alkylamine: Verapamil

      b) Benzothiazepine: Diltiazem

      c) Dihydropyridines: Nifedipine, Felodipine, Amlodipine, Nitrendipine, Nimodipine,

          Lacidipine, Lercanidipine, Benidipine

B. Cardiac depressant:

1. Calcium Channel Blocker:

2. Beta Blocker: Propranolol, Metoprolol, Atenolol and others.

C. Potassium channel opener: Nicorandil

D. Other Drugs: Dipyridamole, Trimetazidine, Ranolazine, Ivabradine, Oxyphedrine