Ch-8.1 D Pharm Pharmacology

Topic: Anti-emetics

Antiemetic drugs are medicines that prevent the nausea or vomiting.

 Classification of drugs:

1. H1antihistamines: Meclizine, Cinnarizine, Cyclizine, Dimenhydrinate, Diphenhydramine.

 2. Muscarinic Antagonist: Hyoscine (Scopolamine).

3. Selective 5-HT3 Antagonists: Ondansetron, Granisetron, Palonosetron & Dolasetron

4. D2 Antagonists:

a) Substituted Benzamides: Metoclopramide, Trimethobenzamide

b) Butyrophenones: Domperidone, Droperidol

c) Phenothiazines: Prochlorperazine, Promethazine & Thiethylperazine

5. Cannabinoids: Dronabinol, Nabilone

6. Glucocorticoids: Dexamethasone, Methylprednisolone

7. Benzodiazepines: Diazepam, Lorazepam

8. Neurokinin-I Antagonist: Aprepitant (oral formulation), Fosaprepitant (IV formulation)