Ch-12.12 D Pharm Pharmacology

Topic: Anti-fungal drugs

Antifungal medicines treat fungal infections. They can fight ringworm, yeast infections and skin and nail infections.

 Classification of Anti-fungal drugs:

Classification based on mechanism of action:

1. Fungal cell wall synthesis inhibition: Caspofungin.

2. Bind to fungal cell membrane ergosterol: Amphotercin–B, Nystatin.

3. Inhibition of ergosterol + lanosterol synthesis: Terbinafine, Naftifine, Butenafine.

4. Inhibition of ergosterol synthesis: Azoles

5. Inhibition of nucleic acid synthesis: 5–Flucytosine.

6. Disruption of mitotic spindle and inhibition of fungal mitosis: Griseofulvin.

7. Miscellaneous: Ciclopirox, Tolnaftate, Haloprogin, Undecylenic acid, Topical azoles.

Classification based on structure:

1. ANTIBIOTICS:

a) Polyene: Amphotericin, Nystatin, Hamycin

b) Heterocyclic benzofuran: Griseofulvin

2. ANTIMETABOLITE: Flucytosine

3. AZOLES:

a) Imidazoles: Ketoconazole, Clotrimazole, Oxiconazole, Miconazole

b) Triazoles: Fluconazole, Itraconazole, Voriconazole,

4. ALLYLAMINES: Terbinafine, Butenafine

5. ECHINOCANDINS: Caspofungin, Micafungin

6. OTHER TOPICAL AGENTS: Tolnaftate, Undecyclinic acid, Benzoic acid