BP301T. PHARMACEUTICAL ORGANIC CHEMISTRY –II (Theory)

UNIT I                              

  • Benzene and its derivatives
    • Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
    • Reactions of benzene – nitration, sulphonation, halogenation- reactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.
    • Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction
    • Structure and uses of DDT, Saccharin, BHC and Chloramine

UNIT II                                                                

  • Phenols* – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
  • Aromatic Amines* – Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts
  • Aromatic Acids* –Acidity, effect of substituents on acidity and important reactions of benzoic acid.

UNIT III

·    Fats and Oils

  1. Fatty acids – reactions.
  • Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
  • Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.

UNIT IV                                                           

  • Polynuclear hydrocarbons:
  • Synthesis, reactions
  • Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

UNIT V                                                                         

  • Cyclo alkanes*

Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only