BP104T. PHARMACEUTICAL INORGANIC CHEMISTRY (Theory)

UNIT I                                                                                                                                

  • Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate.
  • General methods of preparation, assay for the compounds superscripted with asterisk (*), properties and medicinal uses of inorganic compounds belonging to the following classes.
UNIT II                                                            
  • Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.
  • Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance.
  • Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.
UNIT III                
  • Gastrointestinal agents
  1. Acidifiers: Ammonium chloride* and Dil. HCl.
  2. Antacid:    Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture.
  3. Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite.
  4. Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations
UNIT IV                         
  • Miscellaneous compounds
  1. Expectorants: Potassium iodide, Ammonium chloride*.
  2. Emetics: Copper sulphate*, Sodium potassium tartarate.
  3. Haematinics: Ferrous sulphate*, Ferrous gluconate.
  4. Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333.
  5. Astringents: Zinc Sulphate, Potash Alum
UNIT V                                              
  • Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radio isotopes and study of radio isotopes – Sodium iodide I131, Storage conditions, precautions & pharmaceutical application of radioactive substances.