BP104T. PHARMACEUTICAL INORGANIC CHEMISTRY (Theory)
UNIT I
- Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate.
- General methods of preparation, assay for the compounds superscripted with asterisk (*), properties and medicinal uses of inorganic compounds belonging to the following classes.
UNIT II
- Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.
- Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance.
- Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.
UNIT III
- Gastrointestinal agents
- Acidifiers: Ammonium chloride* and Dil. HCl.
- Antacid: Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture.
- Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite.
- Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations
UNIT IV
- Miscellaneous compounds
- Expectorants: Potassium iodide, Ammonium chloride*.
- Emetics: Copper sulphate*, Sodium potassium tartarate.
- Haematinics: Ferrous sulphate*, Ferrous gluconate.
- Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333.
- Astringents: Zinc Sulphate, Potash Alum
UNIT V
- Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radio isotopes and study of radio isotopes – Sodium iodide I131, Storage conditions, precautions & pharmaceutical application of radioactive substances.