BP 204T.PATHOPHYSIOLOGY (THEORY)
Unit I
- Basic principles of Cell injury and Adaptation: Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury, Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, nuclear damage), Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia), Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis &Alkalosis, Electrolyte imbalance.
- Basic mechanism involved in the process of inflammation and repair: Introduction, Clinical signs of inflammation, Different types of Inflammation, Mechanism of Inflammation – Alteration in vascular permeability and blood flow, migration of WBC’s, Mediators of inflammation, Basic principles of wound healing in the skin, Pathophysiology of Atherosclerosis
Unit II
- Cardiovascular System: Hypertension, congestive heart failure, ischemic heart disease (angina, myocardial infarction, atherosclerosis and arteriosclerosis).
- Respiratory system: Asthma, Chronic obstructive airways diseases.
- Renal system: Acute and chronic renal failure.
Unit II
- Haematological Diseases: Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia.
- Endocrine system: Diabetes, thyroid diseases, disorders of sex hormones
- Nervous system: Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression, schizophrenia and Alzheimer’s disease.
- Gastrointestinal system: Peptic Ulcer
·Unit IV
- Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver disease.
- Disease of bones and joints: Rheumatoid arthritis, osteoporosis and gout.
- Principles of cancer: classification, etiology and pathogenesis of cancer.
Unit V
- Infectious diseases: Meningitis, Typhoid, Leprosy, Tuberculosis Urinary tract infections.
- Sexually transmitted diseases: AIDS, Syphilis, Gonorrhea.