Ch-12.11 D Pharm Pharmacology

Topic: Sulphonamides

Sulfonamide is a functional group that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. It contains the sulfonamide chemical group.

 Classification of Sulphonamides:

Classification according to duration of action:

A. Orally absorbable agents

1. Short acting (6-9hrs.): Sulfadiazine, Sulfacytine, Sulfamethizole, Sulfisoxazole

2. Intermediate acting (10-12hrs.): Sulfamethaxazole, Sulfamoxole

3. Long acting(7days): Sulfadoxine, Sulfamethopyrazine

B. Orally non- absorbable agents: Sulfasalazine, Olsalazine

C. Topical agents: Silver sulfadiazine, Sulfacetamide Mafenide

Classification according to therapeutic use:

1. Topically applied sulfonamides

a) for eye infection: Sulfacetamide (10%,20%&30%)

b) for skin infection- Silver sulfadiazine, Mefanide acetate

2. GIT Infections: Succinyl sulfathaizole, Phthalyl sulfathiazole, Sulfaguanidine

3. Meningitis: Sulfadiazine, Sulfadimidine

4. UTI Infections: Sulfioxazole, Sulfamethopyrazine

5. Respiratory tract infections: Sulfaphenazine, Cotrimoxazole

6. Leprosy: Dapsone, Solapsone

7. Drugs for bowel disinfection: Sulfasalazine, Pthalylsulfathiazole

8. Malaria: Sulfadoxine + Pyrimethamine

9. Nocardiosis: Sulfadiazine, Sulfisoxazole